ASSESSMENT OF THE POTENTIAL OF FINE NEEDLE ASPIRATION CYTOLOGY (FNAC) IN THE DIAGNOSIS OF TUMOR AT A PUBLIC MEDICAL COLLEGE HOSPITAL IN BANGLADESH
DOI:
https://doi.org/10.53808/KUS.2010.10.1and2.1012-LKeywords:
Tumor, laboratory diagnosis, FNAC, histopathologyAbstract
We determined the sensitivity, specificity, positive and negative predictive values of physical examination and fine needle aspiration cytology (FNAC) for diagnosis of tumor’s, considering histopathology as standard that included fifty suspected tumor patients. Following the completion of interview for clinical history and physical examination, FNAC and histopathology were performed. Lump was present in 44% cases, weight loss was observed in 42% cases as complaint signs and pain occurred at the site of tumor in 44% cases. Physical examination indicated that 36% cases were malignant and 64% were benign tumors. Histopathological diagnosis of the tumor confirmed that 46% cases were malignant and 54% were benign. Thus, physical examination was sensitive in 52.11%, specific in 77.78%, accurate in 76% and the negative and positive predictive values were 34.37% and 66.57%, respectively. However, FNAC showed 72% neoplasm and 28% non-neoplasm, while histopathology revealed 86% neoplasm and 14% non neoplasm among the patients. So, the sensitivity, specificity, accuracy, false positive and false negative results , positive and negative predictive values of FNAC were 62.50%, 88.46%, 76%, 16.67%, 28.12%, 83.33% and 71.88%, respectively. Particularly in 28% non-neoplasm’s, FNAC showed equal accuracy and sensitivity and that was 50%. In correlation with 27 benign cases and 23 malignant tumors from histopathology, FNAC showed accuracy of 92.60% and 43.48%, respectively. Though FNAC is less sensitive than histopathology in making unequivocal diagnosis of cancer but insignificantly different from histopathology in interpreting atypical or malignant cases of tumors.
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References
Abbas, A.K., Kumar, V. and Fausto, N. 2004. Robins and Cotrans Pathologic Basis of Diseases. WB Saunders Company, New York
Ahmed, I., Chilcote, W.A. and Quinn, C.A. 1997. Stereotactic breast biopsy: a less invasive option. Cleveland Clinic Journal of Medicine 64: 550 –554
Ashcroft, M.W. and Vanherle, A.J. 1981. Management of thyroid nodule-II. Head and Neck Surgery 3: 397-322
Bizjak-Schwarzbartl, M. 1997. Large cell anaplastic Ki-1þnon- Hodgkin’s lymphoma versus Hodgkin’s disease in fine needle aspiration biopsy samples. Acta Cytologica 41: 351–356
Carter, D., Frable, W. and Taylor, W.F. 1988. Fine Needle Aspiration Biopsy: W3 Saunders co., Philadelphia
Cohen, M.B., Rodgers, C. and Hales, M.S. 1987. The importance of training and experience in the interpretation of fine needle aspirates of the breast: analysis by ROC curves. Archives of Pathology and Laboratory Medicine 111:518-520
Carter, T., Feldman, P., Innes, D., Frierson, H. and Frigy, A. 1998. The role of FNA cytology in the diagnosis of lymphoma. Acta Cytologica 32:848–53
Das, D.K. 1999. Value and limitations of fine-needle aspiration cytology in diagnosis and classification of lymphomas: a review. Diagnostic Cytopathology 21: 240–249
Dong, H.Y., Harris, N.L., Preffer, F.I. and Pitman, M.B. 2001. Fine-needle aspiration biopsy in the diagnosis and classification of primary and recurrent lymphoma: a retrospective analysis of the utility of cytomorphology and flow cytometry. Modern Pathology 14: 472–481
Giard, R.W. and Hermans, J. 1992. The value of aspiration cytologic examination of the breast: a statistical review of the medical literature. Cancer 69: 2104 -2110
Katz, R.L. 1997. Controversy in fine-needle aspiration of lymph nodes. A territorial imperative? American Journal of Clinical Pathology 108: 53–55
Martin, H.E., and Ellis, E.D. 1994. Aspiration biospy. Surgery Gynecology And Obstetrics 59 : 578-589
Moriarty, A.T., Banks, E.R. and Bloch, T. 1989. Cytologic criteria for subclassification of Hodgkin’s disease using fine-needle aspiration. Diagnostic Cytopathology 5: 122–125
Mordenti, C., Peris, K., Fargnoli, L.M. and Chimenti, S. 1998. Final report of the technology transfer workshop on breast cancer detection, diagnosis, and treatment. Washington, D.C., USA. May 1-2, 1997. Academic Radiology 5:S465-501
Orell, R.S., Sterret, O.F., Walter, M.N.H. 1992. Manual and Atlas of Fine Needle Aspiration Cytology. Churchl Livingstone, London
Rodrigues, K.E. and Thomson, P. 1992. The Needle aspiration Biopsy. Acta Cytologica 26: 262-264
Schwartz, R.A. 1995. Histopathologic aspects of cutaneous metastatic disease. Journal of the American Academy of Dermatology 33: 649-57
Stewart, C.J.R., Pilotti, S., Palma, S., Alasio, L., Bartoli ,C. and Rilke, F. 1997. Diagnostic assessment of enlarged superficial lymph nodes by fine needle aspiration. Acta Cytologica; 37:853–66.
Schwartz, R. A. 2003. Cutaneous metastatic disease. Journal of the American Academy of Dermatology 33: 161-82
Wilkinson, H., Gelabert, H.A., Hsiu, J.G., Mullen, J.T., Jaffe, A.H.D. and Amato, N.A. 1993. Prospective evaluation of the role of fine needle aspiration biopsy in the diagnosis and management of patients with palpable solid breast lesions. American Surgery 56:263–267
Young, N.A. and Al-Saleem, T. 1999. Diagnosis of lymphoma by fine needle aspiration cytology using the revised European- American classification of lymphoid neoplasms. Cancer 87: 325–345
Young, N.A., Al-Saleem, T.I., Ehya, H. and Smith, M.R. 1998. Utilization of fine-needle aspiration cytology and flow cytometry in the diagnosis and sub-classification of primary and recurrent lymphoma. Cancer 84: 252–261
Zajicek, J. 1974. Introduction to Aspiration Biopsy. Monographs in Clinical Cytology 4: 1-221
Zarbo, R.J., Howanitz, P.J. and Bachner P. 1991. Inter-institutional comparison of performance in breast fine needle aspiration cytology: a Q - probe quality indicator study. Archives of Pathology and Laboratory Medicine 115:743-750
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