TOXICOLOGICAL STUDIES OF ANTIBIOTICS FROM A STRPTOMYCES STRAIN ON LONG EVAN’S RATS
DOI:
https://doi.org/10.53808/KUS.2002.4.1.0148-LKeywords:
Toxicological study, Antibiotic, StreptomyceAbstract
The sub-acute toxicity studies of two antibiotics (S, & SJ, isolated from the culture filtrate of a Streptomyces strain were carried out on long evan's rats. The study included the gross general observation, body weight changes, hematological profiles, such as, total count of RBC & WBC. differential count of WBC, platelet count & hemoglobin percentage, biochemical parameters of blood, such as, SGOT, SGPT, serum alkaline phosphate, serum bilirubin, serum uric acid & scrum urea, and histopathological studies of liver, kidney, heart, lungs & spleen tissues. The antibiotics did not show any abnormalities on the hematological profiles. The body weight and biochemical parameters of blood were found to be slightly changes with respect to that of control but remained within the normal range and statistically insignificant. No detectable abnormalities were observed in the histopathological studies
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