R E L E A S E P A T T E R N A N D P O T E N C Y S T A T U S O F S O M E D I C L O F E N A C S O D I U M E N T E R I C C O A T E D T A B L E T S O F T H E P H A R M A -M A R K E T O F B A N G L A D E S H

M.G.  Hossain; Md.  Saifuzzaman

doi:10.53808/KUS.2002.4.2.0305-L

Authors

M.G. Hossain Pharmacy Discipline, Life Science School, Khulna University, Khulna 9208, Bangladesh
Md. Saifuzzaman Pharmacy Discipline, Life Science School, Khulna University, Khulna 9208, Bangladesh

DOI:

https://doi.org/10.53808/KUS.2002.4.2.0305-L

Keywords:

Diclofenac Sodium; enteric-coated tablets; disintegration test; dissolution test; potency estimation.

Abstract

Fifteen brands of commercially available Diclofenac Sodium enteric-coated tablets were purchased from different regions of Bangladesh and were studied for their in-vitro release behaviors as well as for their potency status. Of the fifteen samples, three (DS-03, DS-10, DS-15) were found noncompliance in respect of disintegration test requirements of USP (United States Pharmacopoeia). All of the brands complied with the USP dissolution specifications for their drug release in the simulated gastric fluids and intestinal fluids except four brands (DS-03, DS-05, DS-10, DS-15) and were found to be substandard in respect of dissolution test. DS-05 complied with the compendial specification in respect of drug release in gastric fluid but failed to comply in intestinal fluids (76.97%). According to BP (British Pharmacopoeia), two brands (DS-10, DS-15) were found to be substandard in respect of potency.

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