PHYTOCHEMICAL SCREENING AND ANALGESIC ACTIVITIES OF TWO BANGLADESHI MEDICINAL PLANTS: Diospyros peregrina and Alocasia fornicata

Shammy  Sarwar; Israt Jahan  Biva; Tajnin  Ahmed; Md. Iqbal  Ahmed; Md. Ashikur  Rahman

doi:10.53808/KUS.2010.10.1and2.1010-L

Authors

Shammy Sarwar Department of Pharmacy, Stamford University Bangladesh, 51, Siddeswari Road, Dhaka 1217, Bangladesh
Israt Jahan Biva Department of Pharmacy, Stamford University Bangladesh, 51, Siddeswari Road, Dhaka 1217, Bangladesh
Tajnin Ahmed Department of Pharmacy, Stamford University Bangladesh, 51, Siddeswari Road, Dhaka 1217, Bangladesh
Md. Iqbal Ahmed Pharmacy Discipline, Khulna University, Khulna 9208, Bangladesh
Md. Ashikur Rahman Department of Pharmacy, Jahangirnagar University, Savar, Dhaka

DOI:

https://doi.org/10.53808/KUS.2010.10.1and2.1010-L

Keywords:

Diospyros peregrina, Alocasia fornicata, analgesic, tail immersion

Abstract

This study deals with crude methanolic extract of the stem bark of Diospyros peregrina and the rhizome of Alocasia fornicata were investigated for phytochemical screening and possible analgesic activity.Preliminary phytochemical screening showed that both extracts possessed the active principles - alkaloids,steroids, flavonoids and tannins. The analgesic activity was evaluated for its central and peripheral pharmacological actions using tail immersion method and acetic acid-induced writhing test in mice respectively. Both extracts produced a significant increase in pain threshold in tail immersion methods in a dose dependent manner. The crude extracts displayed significant reduction in acetic acid induced writhing in mice with a maximum effect of 72.1 % reduction at 500 mg/kg and 88.05 % reduction at 400 mg/kg body weight which are comparable to the standard analgesic drug, diclofenac sodium (78.09 %).

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