STRESS INDUCED NEURO-ENDOCRINE-IMMUNE SYSTEM ALTERATION AND ITS RELATION WITH AUTOIMMUNE/INFLAMMATORY DISEASES: A REVIEW

Mahbub-E Sobhani; A.T.M.K.  Islam; E.K.  Chowdhury; N.  Haque; A.K.M.  Wahiduzzaman; A.  Ahmed; A. H. G.  Morshed; S. M. A.  Masood; Md. Maruf- Uzzaman

doi:10.53808/KUS.2006.7.1.0525-L

Authors

Mahbub-E Sobhani Biotechnology and Genetic Engineering Discipline, Khulna University, Khulna 9208, Bangladesh
A.T.M.K. Islam Hasina Samad Holistic Health Centre, Fidelity Trust, Khulna 9100, Bangladesh
E.K. Chowdhury Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka 1000, Bangladesh
N. Haque Biotechnology and Genetic Engineering Discipline, Khulna University, Khulna 9208, Bangladesh
A.K.M. Wahiduzzaman Hasina Samad Holistic Health Centre, Fidelity Trust, Khulna 9100, Bangladesh
A. Ahmed Biotechnology and Genetic Engineering Discipline, Khulna University, Khulna 9208, Bangladesh
A. H. G. Morshed Biotechnology and Genetic Engineering Discipline, Khulna University, Khulna 9208, Bangladesh
S. M. A. Masood Biotechnology and Genetic Engineering Discipline, Khulna University, Khulna 9208, Bangladesh
Md. Maruf- Uzzaman Biotechnology and Genetic Engineering Discipline, Khulna University, Khulna 9208, Bangladesh

DOI:

https://doi.org/10.53808/KUS.2006.7.1.0525-L

Keywords:

Stress, cortisol, HPA axis, autoimmune disease, neuro endocrine immune system, inflammation

Abstract

In recent years a novel scientific discipline called psychoneuroimmunology has emerged that examines complex interdependence of the mind, brain, endocrine and immune system in health and disease. Homeostasis (a self-referral phenomenon) plays an important role in keeping a person healthy and it has a fundamental role in host defense. Many studies show that stress (acute or chronic) creates disorder especially in the immune regulation. In this study a typical nervous-endocrine and immune network has been shown in case of stress. From this network Corticotrophin Releasing Factor (CRF), Adrenocorticotrophic Hormone (ACTH), Growth Hormone(GH), prolactin (PRL), Glucocorticoids (GC) and catecholamine are found as important endocrine factors and T cells, B cells, monocytes/macrophages, Natural Killer(NK) cells and their cytokines that is Tumor Necrosis Factor-a (TNF-a), Gamma Interferon (IFN-g) and interleukins such as IL-1, IL-2, IL-4, IL-6, IL-10 etc. are found as important immune factors in most stress related studies. Finally, autoimmune/ inflammatory disease is shown in relation to above endocrine and immune factors. In summary, we have demonstrated psychoneuroimmune alteration in stress and its association with autoimmune/inflammatory disease. The present study suggests the importance of restoring self-referral organization in the body.

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