AN INVESTIGATION FOR ANTIMICROBIAL POTENCY OF SOME COMMONLY USED ANTIBIOTICS (CAPSULE) MANUFACTURED BY VARIOUS PHARMACEUTICAL COMPANIES IN BANGLADESH

Authors

  • N.I. Siddiqui Biotechnology Discipline, Khulna University, Khulna 9208, Bangladesh
  • M. Shahjahan Department of Biochemistry, University of Rajshahi, Rajshahi 6205, Bangladesh

DOI:

https://doi.org/10.53808/KUS.2000.2.1.159-165-Ls

Keywords:

Biopotency; Ampicillin trihydrate; Amoxycillin trihydrate; Oxytetracycline hydrochloride

Abstract

Antibiotics are indispensable drugs for the treatment of infectious diseases. For proper treatment, antibiotics as well as all drugs should have a standard level of purity. But in our country some pharmaceutical companies are producing impure and substandard antibiotics as have been reported in s everal newspapers. Consumption of these antibiotics may lead to the development of serious complexities. For this reason, we took the initiative to investigate the biopotency of three widely used antibiotics- ampicillin trihydrate, amoxycillin trihydrate and oxytetracycline hydrochloride. Antimicrobial potency of the antibiotics was determined by disc diffusion method (Beur et al ., 1993) in nutrient agar and also by minimum inhibitory concentration (MIC) (Annon, 1965). It is evident from the study that some of the pharmaceutical companies are producing substandard antibiotics and physicians and consumers should be careful about the antibiotics.

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References

Annon, 1965. United States Pharmacopoeia . 17th edition, 4th Park Avenue, New York, pp. 522-562.

Annon, 1993. British Pharmacopoeia, Vol. I and II. pp. 113-115, 930-934.

Beur, A.W., Kirby, Q.M.M., Sherris, J.C. and Turck, M., 1993. Antibiotic susceptibility test by a standard single disc method. American Journal of Clinical Pathology, 44: 493-496.

Burger, A., 1970. Medicinal Chemistry, Part I and II. 3rd edition, Wiley-Interscience, New York, p. 1070.

Gilman, A.G., 1996. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 9th edition, McGraw- Hill, New York, pp. 1078-1085.

Huq, I. and Aziz, K.M.S. 1977. Changing antibiotic sensitivity patterns of the commonly occurring organisms causing dysentery. Bangladesh Medical Journal, 5:119-125.

Miles, A.A., Misra, S.S. and Irwin, J.O., 1938. The estimation of bactericidal power of the blood. J. Hyg. 38: 732-749.

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Published

29-05-2000

How to Cite

[1]
N. . Siddiqui and M. Shahjahan, “AN INVESTIGATION FOR ANTIMICROBIAL POTENCY OF SOME COMMONLY USED ANTIBIOTICS (CAPSULE) MANUFACTURED BY VARIOUS PHARMACEUTICAL COMPANIES IN BANGLADESH”, Khulna Univ. Stud., pp. 159–165, May 2000.

Issue

Section

Life Science