SYNTHESIS AND CHARACTERIZATION OF SOME NOVEL HETERONUCLEAR BIS-THIAZOLIDINONE DERIVATIVES AND EVALUATION OF ITS ANTIMICROBIAL AND IN VITRO CYTOTOXIC PROPERTY

Sabikun  Naher; Dr. Md. Abdur  Rashid

doi:10.53808/KUS.2022.ICSTEM4IR.0010-se

Authors

Sabikun Naher Department of Chemistry, BUET, Dhaka 1000, Bangladesh
Dr. Md. Abdur Rashid Department of Chemistry, BUET, Dhaka 1000, Bangladesh

DOI:

https://doi.org/10.53808/KUS.2022.ICSTEM4IR.0010-se

Keywords:

Thiosemicarbazone, 1,3-Thiazoldinone, antimicrobial & antifungal activity, cytotoxic activity.

Abstract

A series of novel bis-thiazolidinone derivatives 3(a-j) have been synthesized by the cyclization of thiosemicarbazones 2(a-j) with chloroacetic acid and sodium acetate. The integrated heterocyclic compounds were featured by chemical and spectroscopic methods such as IR, ¹H NMR and ¹³C NMR. All the synthesized compounds have been screened for their antimicrobial activity against Gram-positive and Gram-negative bacteria such as Staphylococcus Aureus, Bacillus licheniformis, Klebsiella pneumoniae, Esherichia coli and antifungal activity against Aspergillus niger and in vitro cytotoxic activity against human cancer cell line (HeLa cell) and Vero cell line, using MTT assays but showed no activity.

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