A SYSTEMATIC REVIEW ON CHEMICAL AND PHARMACOLOGICAL ACTIVITIES OF  EXCOECARIA AGALLOCHA: A POTENTIAL SUNDARBAN PLANT

Shaikh Jamal Uddin; Tasfiya Rufaidah  Ahnaf; Pritam  Sarkar; Md. Emam  Shikdar; Sudipto  Saha

doi:10.53808/KUS.2023.20.02.1092-ls

Authors

Shaikh Jamal Uddin Khulna University
Tasfiya Rufaidah Ahnaf Pharmacy Discipline, Khulna University
Pritam Sarkar Pharmacy Discipline, Khulna University
Md. Emam Shikdar Pharmacy Discipline, Khulna University
Sudipto Saha Shaheed Abu Nasar Specialized Hospital, Khulna

DOI:

https://doi.org/10.53808/KUS.2023.20.02.1092-ls

Keywords:

Excoecaria agallocha, Anti-epileptic property, Diterpenoids, Anti-inflammatory, cytotoxic,

Abstract

Among various plants in the Mangrove Forest of the tropical and subtropical region, E. agallocha is notable for possessing multifarious pharmacological activity. As E. agallocha belongs to the Euphoriaceae family, this plant is rich in many classes of phytochemicals that are therapeutically potent such as Diterpenoids, Triterpenoids, Alkaloids, Polyphenol, Sterol, Flavonoids, Tanine, Flavanone, etc. Its ancient use in the treatment of disorders such as epilepsy, rheumatism, ulcer, leprosy, and others has attracted the interest of researchers, who are now studying different parts of the plant. Plant parts have been studied for reducing inflammation, anti-microbial, anti-epileptic, and cytotoxic effects in several research. Phytoconstituents responsible for pharmacological activities have been distinguished and their possible mechanism of action along with IC₅₀ value has been presented. From wood, roots, and stems of the plant physiologically active constituents such as Agallochin, ent-kauran-16â-ol-3-one, Chebulagic acid, Betulinic acid, Betulonic acid, Corilagin, Geraniin, Excoecarin, Agallochaexcoerin, Vanillic acid are described as pharmacologically potent molecules as they interact with certain biomolecules and precipitate changes in the physiological state of the body. This review is elucidating the likely mechanism of action of each of these plant compounds that provide particular biological activity.

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