PHYTOCHEMICAL AND BIOLOGICAL INVESTIGATION OF SEEDS OF Hyptis suaveolens
DOI:
https://doi.org/10.53808/KUS.2010.10.1and2.1011-LKeywords:
Hyptis suaveolens, analgesic activity, antidiarrhoeal activity, cytotoxic activityAbstract
The crude ethanolic extract of the seeds of Hyptis suaveolens was evaluated for its analgesic,antidiarrhoeal and cytotoxic activities. The extract significantly and dose dependently inhibited the acetic acid induced writhing in mice (69.7%, P < 0.001 and 60.6%, P < 0.001 for 500 and 250 mg/kg body weight,respectively), comparable to the standard drug diclofenac sodium. The extract also decreased the frequency of defecation and increased mean latent period significantly (P< 0.05) at the doses of 250 and 500 mg/kg body weight respectively compared with the control group. Moreover, it displayed considerable general toxicity towards brine shrimps. The LC50 value of the extract was 80 µg/ml which was comparable to that of standard drug chloramphenicol (43 µg/ml). All the results tend to justify the traditional uses of the seeds of Hyptis suaveolens.
Downloads
References
Ahmed, F., Selim, M.S.T., Das, A.K. and Choudhuri, M.S.K. 2004. Anti-inflammatory and antinociceptive activities of Lippia nodiflora Linn. Pharmazie 59: 329-333
Beubler, E. and Juan, H. 1979. Effect of ricinoleic acid and other laxatives in net water flux and prostaglandin E release by the rat colon. J. Pharm. Pharmacol. 31: 681-685
Bittar, M., De Souza, M.M., Yunes, R.A., Lento, R., Delle Monache, F. and Cechinel, F.V. 2000. Antinociceptive activity of I3,II8-binaringenin, a biflavonoid present in plants of the Guttiferae. Planta Medica 66 (1): 84-86
Chatterjee, T.K. 1993. Handbook of laboratory Mice and Rats. Jadavpur University, India
Derardt, R., Jougney, S., Delevalcee, F. and Falhout, M. 1980. Release of prostaglandins E and F in an algogenic reaction and its inhibition. European Journal of Pharmacology 51: 17–24
Duke, J.A. 1992. Handbook of biologically active phytochemicals and their activities. CRC Press, Boca,Raton, FL
Eshilokun, A.O., Kasali, A.A. and Giwa-Ajeniya, A.O. 2003. Chemical composition of essential oils of Hyptis suaveolens (Lin.) poit leaves from Nigeria. Flavour and Fragrance Journal 45: 211-321
Evans, W.C. 1989. Trease and Evan’s Pharmacognosy. Cambridge University Press, London
Ghani, A. 2003. Medicinal Plants of Bangladesh. The Asiatic Society of Bangladesh
McLaughlin, J.L., Anderson, J.E. and Chang, C.J. 1988. Bioactive components of Allamanda schottii. Journal of Natural Products 51(2): 307-308
Meyer, S. 1982. Phytochemical methods (a guide to modern techniques to plant analysis). Champan and Hall, USA
Pathak, D., Pathak, K. and Singla, A.K. 1991. Flavonoids as medicinal agents: recent advances. Fitoterapia 62(5): 371-389
Racusen, L.C. and Binder, H.J. 1979. Ricinoleic acid stimulation of active anion secretion in colonic mucosa of the rat. Journal of Clin. Invest 63: 743-749
Rahman, S., Ali, E. and Haque, R. 2007. Pharmacological profiles of Holarhena antidysenterica (L.) wall bark. Ori. Pharm. and Exper. Med. 7(2): 157-161
Shirwaikar, A., Shenoy, R., Udupa, A.L., Udupa, S.L. and Shetty, S. 2003. Wound healing property of ethanolic extract of leaves of Hyptis suaveolens with supportive role of antioxidant enzymes. Indian Journal of Experimental Biology 34: 523-526
Taesotikul, T., Panthong, A., Kanjanapothi, D., Verpoorte, R. and Scheffer, J.J.C. 2003. Antiinflammatory, antipyretic and antinociceptive activities of Tabernaemontana pandacaqui Poir. Journal of Ethnopharmacology 84: 31-35
Wagner H., Bladt, S. and Zgainski E.M. 1984. Plant drug analysis. Springer, Berlin
Whittle, B.A. 1964. The use of changes in capillary permeability in mice to distinguish between narcotic and non-narcotic analgesic. British Journal of Pharmacological Chemotherapy 22: 246
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Khulna University Studies
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
